What acid-base imbalance typically indicates the need for Continuous Renal Replacement Therapy (CRRT)?

The need for Continuous Renal Replacement Therapy (CRRT) is typically indicated by the presence of metabolic acidosis. Metabolic acidosis occurs when there is an excess of acid in the body or a significant loss of bicarbonate, leading to a decreased pH. This condition is often seen in patients with acute or chronic kidney injury, as the kidneys are unable to excrete enough acid or produce adequate bicarbonate to maintain normal acid-base balance.

CRRT is specifically designed to assist in managing severe metabolic disturbances, especially in critically ill patients who cannot tolerate conventional dialysis methods due to hemodynamic instability. Metabolic acidosis often manifests with clinical signs such as increased respiratory rate as the body tries to compensate by blowing off carbon dioxide, but this may not be sufficient in severe cases.

Other choices, while representing various imbalances, do not align with the typical indications for CRRT. For example, while respiratory acidosis and alkalosis are linked to pulmonary issues, they are not usually corrected solely through renal replacement therapies. Metabolic alkalosis, on the other hand, often results from conditions like prolonged vomiting or excessive bicarbonate administration and is also not an indication for CRRT. Thus, CRRT is primarily indicated for cases of metabolic acidosis, particularly