What is a known risk factor for developing deep vein thrombosis?

The association between smoking and an increased risk of developing deep vein thrombosis (DVT) is well-established in medical literature. Smoking contributes to various pathological changes in the vascular system, including endothelial damage, increased blood viscosity, and hypercoagulability, all of which can facilitate the formation of thrombi in the venous system.

In contrast, age under 30 is generally not considered a significant risk factor for DVT, as the prevalence of this condition typically rises with advancing age. Regular exercise is associated with improved circulation and a decreased risk of clot formation; thus, it acts as a protective factor rather than a risk factor. Additionally, low body mass index (BMI) is usually linked with a lower risk of DVT, as obesity is a known risk factor due to the effects of excess body weight on venous return and venous stasis.

Hence, smoking stands out as a clear risk factor due to its direct contribution to the mechanisms that lead to thrombosis.