Which medication is known to potentially cause lupus-like symptoms?

Hydralazine is known to potentially cause lupus-like symptoms due to its ability to induce a drug-induced lupus erythematosus (DILE) condition. This condition mimics systemic lupus erythematosus (SLE) and is characterized by symptoms such as arthritis, skin rashes, and serositis. The mechanism behind this involves the drug triggering an autoimmune response in some individuals, often related to the inhibition of histone deacetylases or alteration in immune responses.

Procainamide also has the potential to cause lupus-like symptoms and is indeed one of the classic drugs linked to DILE. It is an antiarrhythmic medication. Its side effects can resemble those of SLE, which can lead to symptoms similar to those seen in lupus patients. Therefore, it is important to monitor patients on procainamide for any signs that may suggest the development of lupus-like symptoms.

Ibuprofen and acetaminophen are primarily analgesic and antipyretic medications and are not associated with the development of lupus-like symptoms. While they are useful for pain management, they do not have the same immunological effects as hydralazine or procainamide that could trigger such conditions.