While on methotrexate, which lab values should be monitored?

Monitoring liver function tests is essential for patients on methotrexate due to the drug's potential hepatotoxicity. Methotrexate can cause liver damage, especially with long-term use or at higher doses. Periodic liver function tests help detect any early signs of hepatic injury, enabling timely intervention to prevent significant liver damage.

Although other lab values listed, such as complete blood counts and renal function tests, are also important in the management of patients on methotrexate, the specific emphasis on liver function tests highlights a critical aspect of patient safety. Monitoring kidney function is especially relevant due to methotrexate's renal clearance, but the potential impact on liver health makes liver function tests particularly significant in this context.

Ensuring that liver enzymes remain within normal limits helps guide treatment decisions and adjust dosages accordingly, thereby reducing the risk of complications associated with methotrexate therapy.